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Since, both human (153, 155) and murine (163, 164) LN metastases can seed distant metastases, the abundance of heterogeneous cancer cell subclones in LNs could potentially give rise to more treatment-resistant cancer cells, such as the ferroptosis-resistant clones ( In the early stage of cancer progression, the sentinel LNs likely retain anti-cancer immunity to prevent cancer cell intravasation and metastasis through blood circulation